2018 marks the first time a European grand tour will begin outside of Europe! 

Two road stages, as well as a time trial, will take place in Israel, marking the opening of the 2018 race, ahead of a transfer to Italy. Read more

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The plan is for a Giro big start based around the holy city of Jerusalem. After a possible time trial to kick off the race on May 5, it would continue with two road stages, one to the south, and one possibly ending in Tel Aviv.
Read more at http://www.cyclingweekly.com/news/racing/giro-ditalia/giro-ditalia-route-192184#Z4qlYi0Zux51X0zz.99